Cavalier King Charles Spaniel
Chiari-like Malformation and Syringomyelia
The observable physical or biochemical characteristics of an organism, as determined by both genetic makeup and environmental influences.
DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms
It involves two aspects:
1) identifying the phenotypic variations that occur in the disorder
2) collecting suitable DNA of these phenotypic variations
In 2003 Dr Guy Roulaeu, now at CHU Sainte Justine Research Centre in Montreal, Canada, agreed to take the research forward and appointed Dr Zoha Kibar to oversee the mammoth task of finding the gene/s. in 2004, in collaboration with Dr Berge Minassion at Sick Kids Toronto, a grant from the Cavalier Health Foundation (#104) was approved to archive Cavalier DNA to be used in a genome scan. This was the first step taken which links human and canine interests, recognizing the valuable contribution that dogs can make towards understanding the etiology in human Chairi and Syringomyelia.